Multi-institutional retrospective analysis of learning curves on dosimetry and operation time before and after introduction of intraoperatively built custom-linked seeds in prostate brachytherapy.

This multi-institutional retrospective analysis examined learning curves for dosimetric parameters and operation time after introduction of intraoperatively built custom-linked (IBCL) seeds. Data from consecutive patients treated with seed implantation before and after introduction of IBCL seeds (loose seed, n = 428; IBCL seed, n = 426) were collected from 13 centers.

Dose-volume histogram parameters, operation times, and seed migration rates were compared before and after introduction of IBCL seeds. At the 1-month CT analysis, no significant differences were seen in dose to 90% of prostate volume between before and after IBCL seed introduction. No learning curve for dosimetry was seen. Prostate and rectal volume receiving at least 150% of prescription dose (V150 and RV150) were higher in the loose-seed group than in the IBCL-seed group. Operation time was extended by up to 10 min when IBCL seeds were used, although there was a short learning curve of about five patients. The percentage of patients with seed migration in the IBCL-seed group was one-tenth that in the loose-seed group. Our study revealed no dosimetric demerits, no learning curve for dosimetry, and a slightly extended operation time for IBCL seeds. A significant reduction in the rate of seed migration was identified in the IBCL-seed group.

Journal of radiation research. 2015 Oct 22 [Epub ahead of print]

Hiromichi Ishiyama, Takefumi Satoh, Atsunori Yorozu, Shiro Saito, Masaaki Kataoka, Katsuyoshi Hashine, Ryuji Nakamura, Susumu Tanji, Koji Masui, Koji Okihara, Toshio Ohashi, Tetsuo Momma, Manabu Aoki, Kenta Miki, Masako Kato, Masashi Morita, Norihisa Katayama, Yasutomo Nasu, Takashi Kawanaka, Tomoharu Fukumori, Fumitaka Ito, Ryoichi Shiroki, Hiroyuki Baba, Akito Inadome, Yasuo Yoshioka, Hitoshi Takayama, Kazushige Hayakawa

Department of Radiology and Radiation Oncology, Kitasato University School of Medicine, 1-15-1 Kitasato, Sagamihara 252-0329, Japan, Department of Urology, Kitasato University School of Medicine, 1-15-1 Kitasato, Sagamihara 252-0329, Japan. , Department of Radiology, National Hospital Organization Tokyo Medical Center, 2-5-1 Higashigaoka, Meguro-ku, Tokyo 152-8902, Japan. , Department of Urology, National Hospital Organization Tokyo Medical Center, 2-5-1 Higashigaoka, Meguro-ku, Tokyo 152-8902, Japan. , Department of Radiation Oncology, National Hospital Organization Shikoku Cancer Center, Kou-160, Minamiumemoto-Machi, Matsuyama, Ehime 791-0280, Japan. , Department of Urology, National Hospital Organization Shikoku Cancer Center, Kou-160, Minamiumemoto-Machi, Matsuyama, Ehime 791-0280, Japan. , Department of Radiology, Iwate Medical University School of Medicine, Uchimaru 19-1, Morioka 020-8505, Japan. , Department of Urology, Iwate Medical University School of Medicine, Uchimaru 19-1, Morioka 020-8505, Japan. , Department of Radiology, Kyoto Prefectural University of Medicine, 465 Kajiicho, Kawaramachi-Hirokoji, Kamigyoku, Kyoto 602-8566, Japan. , Department of Urology, Kyoto Prefectural University of Medicine, 465 Kajiicho, Kawaramachi-Hirokoji, Kamigyoku, Kyoto 602-8566, Japan. , Department of Radiology, Keio University School of Medicine, 35 Shinanomachi, Shinjuku-ku, Tokyo 160-8582, Japan. , Department of Urology, National Hospital Organization Saitama National Hospital, 2-1 Suwa, Wakho City, Saitama 351-0102, Japan. , Department of Radiology, The Jikei University School of Medicine, 3-25-8 Nishi-Shimbashi, Minato-Ku, Tokyo 105-8461, Japan. , Department of Urology, The Jikei University School of Medicine, 3-25-8 Nishi-Shimbashi, Minato-Ku, Tokyo 105-8461, Japan. , Department of Radiology, Showa University School of Medicine, Showa University Koto Toyosu Hospital, 5-1-38 Toyosu Koto-ku, Tokyo 135-0061, Japan. , Department of Urology, Showa University Koto Toyosu Hospital, 5-1-38 Toyosu Koto-ku, Tokyo 135-0061, Japan. , Department of Radiology, Okayama University School of Medicine, 2-5-1 Shikata-cho, Okayama 700-8558, Japan. , Department of Urology, Okayama University School of Medicine, 2-5-1 Shikata-cho, Okayama 700-8558, Japan. , Department of Radiology, Tokushima University School of Medicine, 3-18-15 Tokushima, Kuramoto-cho, Tokushima 770-8503, Japan. , Department of Urology, Tokushima University School of Medicine, 3-18-15 Tokushima, Kuramoto-cho, Tokushima 770-8503, Japan. , Department of Radiology, Fujita Health University School of Medicine, 1-98 Dengakugakubo, Kutsukake-cho, Toyoake, Aichi 470-1192, Japan. , Department of Urology, Fujita Health University School of Medicine, 1-98 Dengakugakubo, Kutsukake-cho, Toyoake, Aichi 470-1192, Japan. , Department of Radiology, Japanese Red Cross Kumamoto Hospital, 2-1-1 Higashiku Nagamine Minami, Kumamoto City 861-8520, Japan. , Department of Urology, Japanese Red Cross Kumamoto Hospital, 2-1-1 Higashiku Nagamine Minami, Kumamoto City 861-8520, Japan. , Department of Radiation Oncology, Osaka University Graduate School of Medicine, 2-2 Yamadaoka, Suita, Osaka 565-0871, Japan. , Department of Urology, Osaka University School of Medicine, 2-2 Yamadaoka, Suita, Osaka 565-0871, Japan. , Department of Radiology and Radiation Oncology, Kitasato University School of Medicine, 1-15-1 Kitasato, Sagamihara 252-0329, Japan.

PubMed

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