To investigate the efficacy of androgen deprivation treatment (ADT) between continuous and intermittent ADT.
Between January 2006 and May 2015, 603 patients were selected and divided into continuous ADT (CADT) (n=175) and intermittent ADT (IADT) (n=428) groups.
The median follow-up in this study was 48. 19 (1. 0-114. 0) months. The primary end point was time to castration resistant prostate cancer (CRPC). The types of ADT were monotherapy and maximal androgen blockade (i. e. , luteinizing hormone-releasing hormone agonist and antiandrogen).
The characteristics of patients showed no significant differences between the CADT and IADT groups, except for the Gleason score (p
This study found that IADT produces a longer duration in median time to CRPC than does CADT.
Korean journal of urology. 2015 Oct 13 [Epub]
Ja Yoon Ku, Jeong Zoo Lee, Hong Koo Ha
Department of Urology, Pusan National University Hospital, Pusan National University School of Medicine, Busan, Korea. , Department of Urology, Pusan National University Hospital, Pusan National University School of Medicine, Busan, Korea. , Department of Urology, Pusan National University Hospital, Pusan National University School of Medicine, Busan, Korea. ; Biomedical Research Institute, Pusan National University Hospital, Busan, Korea.