The value of FDG-positron emission tomography/computed tomography (PET/CT) for detecting prostate cancer is unknown. We aimed to investigate the clinical value of incidental prostate FDG uptake on PET/CT scans.
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We reviewed 6128 male patients who underwent FDG-PET/CT scans and selected cases that reported hypermetabolic lesion in the prostate. The patients who have prior history of prostate carcinoma or prostate surgery were excluded from the study. We have analyzed the correlation between PET/CT findings and serum prostate-specific antigen (PSA) levels, imaging (USG), urological examinations and biopsy. Incidental 18F-FDG uptake of the prostate gland was observed in 79 patients (1. 3%). While sixteen of them were excluded due to inadequate clinical data, the remaining 63 patients were included for further analysis. The patients were divided into two groups; 8 patients (12. 7%) in the malignant group and 55 patients (87. 3%) in the benign group. The SUVmax values were not significantly different between the two groups. In 6 (75%) patients with prostate cancer, FDG uptake was observed focally in the peripheral zone of the prostate glands. There was no significant correlation between the SUVmax and the PSA levels. Incidental 18F-FDG uptake in the prostate gland is a rare condition, but a substantial portion of it is associated with the cancer. Benign and malignant lesions of the prostate gland in FDG-PET/CT imaging could not be reliably distinguished. The peripheral focally FDG uptake of prostate glands should be further examined with the clinical and labaratory evaluations.
International journal of clinical and experimental medicine. 2015 Jul 15*** epublish ***
Ertan Sahin, Umut Elboga, Ebuzer Kalender, Mustafa Basıbuyuk, Hasan Deniz Demir, Yusuf Zeki Celen
Department of Nuclear Medicine, Namik Kemal University Tekirdag, Turkey. , Department of Nuclear Medicine, Gaziantep University Gaziantep, Turkey. , Department of Nuclear Medicine, Mustafa Kemal University Hatay, Turkey. , Department of Nuclear Medicine, Gaziantep University Gaziantep, Turkey. , Department of Nuclear Medicine, Gaziantep University Gaziantep, Turkey. , Department of Nuclear Medicine, Gaziantep University Gaziantep, Turkey.