Vitamin D and prostate cancer prognosis: a Mendelian randomization study

Decreased vitamin D levels have been associated with prostate cancer, but it is unclear whether this association is causal. A functional single-nucleotide polymorphism (SNP) in the group-specific component (GC) gene (T > G, rs2282679) has been associated with 25-hydroxy (25-OH) vitamin D and 1.

25 dihydroxy (1 25-OH2) vitamin D levels

To examine the hypothesized inverse relationship between vitamin D status and prostate cancer, we studied the association between this SNP and prostate cancer outcome in the prospective PROCAGENE study comprising 702 prostate cancer patients with a median follow-up of 82 months

GC rs2282679 genotypes were not associated with biochemical recurrence [hazard ratios (HR) 0 91, 95 % confidence interval (CI) 0 73-1 12; p = 0 36], development of metastases (HR 1 20, 95 % CI 0 88-1 63; p = 0 25) or overall survival (HR 1 10; 95 % CI 0 84-1 43; p = 0 50)

A causal role of vitamin D status, as reflected by GC rs2282679 genotype, in disease progression and mortality in prostate cancer patients is unlikely

World journal of urology 2015 Jul 25 [Epub ahead of print]

Olivia Trummer, Uwe Langsenlehner, Sabine Krenn-Pilko, Thomas R Pieber, Barbara Obermayer-Pietsch, Armin Gerger, Wilfried Renner, Tanja Langsenlehner

Division of Endocrinology and Metabolism, Department of Internal Medicine, Medical University of Graz, Graz, Austria



Newsletter subscription

Free Daily and Weekly newsletters offered by content of interest

The fields of GU Oncology and Urology are rapidly advancing. Sign up today for articles, videos, conference highlights and abstracts from peer-review publications by disease and condition delivered to your inbox and read on the go.