OBJECTIVES: There is little data about the clinical value of core length for prostate biopsy (PBx).
We investigated the clinical values of various clinicopathological biopsy-related parameters, including core length, in the contemporary multi-core PBx.
PATIENTS AND METHODS: Medical records of 5,243 consecutive patients who received PBx at our institution were reviewed. Among them, 3,479 patients with prostate-specific antigen (PSA) ≤ 10ng/ml level who received transrectal ultrasound (TRUS)-guided multi (≥12)-core PBx at our institution were analyzed for prostate cancer (PCa). Gleason score upgrading (GSU) was analyzed in 339 patients who were diagnosed with low-risk PCa and received radical prostatectomy. Multivariate logistic regression analyses for PCa detection and prediction of GSU were performed.
RESULTS: The mean age and PSA of the entire cohort were 63.5 years and 5.4ng/ml, respectively. The overall cancer detection rate was 28.5%. There was no statistical difference in core length between patients diagnosed with PCa and those without PCa (16.1 ± 1.8 vs 16.1 ± 1.9mm, P = 0.945). The core length was also not significantly different (16.4 ± 1.7 vs 16.4 ± 1.6mm, P = 0.889) between the GSU group and non-GSU group. Multivariate logistic regression analyses demonstrated that the core length of PBx did not affect PCa detection in TRUS-guided multi-core PBx (P = 0.923) and was not prognostic for GSU in patients with low-risk PCa (P = 0.356).
CONCLUSIONS: In patients undergoing contemporary multi-core PBx, core length may not have significant impact on PCa detection and also GSU following radical prostatectomy among low-risk PCa group.
Written by:
Lee S, Jeong SJ, Hwang SI, Hong SK, Lee HJ, Byun SS, Choe G, Lee SE. Are you the author?
Department of Urology, Seoul National University Bundang Hospital, Seongnam, Korea; Department of Radiology, Seoul National University Bundang Hospital, Seongnam, Korea; Department of Pathology, Seoul National University Bundang Hospital, Seongnam, Korea.
Reference: PLoS One. 2015 Apr 14;10(4):e0123704.
doi: 10.1371/journal.pone.0123704
PubMed Abstract
PMID: 25875823