Vascular-targeted photodynamic therapy with TOOKAD® Soluble in localized prostate cancer: Standardization of the procedure - Abstract

INTRODUCTION: Vascular-targeted photodynamic therapy with TOOKAD® Soluble is an innovative focal therapy procedure assessed in localized prostate cancer treatment.

MATERIALS AND METHODS: This mini-invasive technique destroys targeted tissues using a photosensitizer [TOOKAD® Soluble (WST11), STEBA Biotech] activated by laser light in the presence of oxygen. Its application for prostate cancer requires intravenous infusion of TOOKAD® Soluble and the illumination of the targeted area by transperineal optical fibers inserted under trans-rectal ultrasound guidance under general anesthesia.

CONCLUSION: Based on the experience gained through hundreds of procedures, we describe here the standardized technique of vascular-targeted photodynamic therapy with TOOKAD® Soluble defined during the phase II and III trials.

Written by:
Azzouzi AR, Lebdai S, Benzaghou F, Stief C.   Are you the author?
Urology Department, CHU Angers, 4 rue Larrey, 49933, Angers Cedex 9, France.  

Reference: World J Urol. 2015 Mar 19. Epub ahead of print.
doi: 10.1007/s00345-015-1535-2

PubMed Abstract
PMID: 25786708 Prostate Cancer Section