Feasibility of multiparametric prostate magnetic resonance imaging in the detection of cancer distribution: Histopathological correlation with prostatectomy specimens - Abstract

PURPOSE: To prevent overtreatment, it is very important to diagnose the precise distribution and characteristics of all cancer lesions, including small daughter tumors.

The purpose of this study was to evaluate the efficacy of T2-weighted magnetic resonance imaging (T2W), diffusion-weighted magnetic resonance imaging (DWI), magnetic resonance spectroscopy (1H-MRS), and prostate biopsy (PBx) in the detection of intraprostatic cancer distribution.

METHODS: All patients underwent T2W, DWI, 1H-MRS, and PBx followed by radical prostatectomy (RP). Individual prostates were divided into 12 segmental regions, each of which was examined for the presence or absence of malignancy on the basis of T2W, DWI, 1H-MRS, and PBx, respectively. These results were compared with the histopathological findings for RP specimens.

RESULTS: We included 54 consecutive patients with biopsy-proven prostate cancer (mean age, 62.7 years; median prostate-specific antigen level, 5.7 ng/mL) in this study. We could detect cancer in 247 of 540 evaluable lesions. The area under the receiver operator characteristic curve analysis yielded a higher value for DWI (0.68) than for T2W (0.65), 1H-MRS (0.54), or PBx (0.56). In 180 cancerous regions of RP specimens with false-negative PBx results, T2W+DWI had the highest positive rate (53.3%) compared with that of each sequence alone, including T2W (45.6%), DWI (41.1%), and 1H-MRS (30.0%).

CONCLUSIONS: Multiparametric magnetic resonance imaging (T2W, 1H-MRS, DWI) enables the detection of prostate cancer distribution with reasonable sensitivity and specificity. T2W+DWI was particularly effective in detecting cancer distribution with false-negative PBx results.

Written by:
Kitamura K, Muto S, Yokota I, Hoshimoto K, Kaminaga T, Noguchi T, Sugiura S, Ide H, Yamaguchi R, Furui S, Horie S.   Are you the author?
Department of Urology, Teikyo University School of Medicine, Tokyo, Japan; Department of Urology, Juntendo University, Graduate School of Medicine, Tokyo, Japan; School of Integrated Health Science, Faculty of Medicine, The University of Tokyo, Tokyo, Japan; Departments of Pathology, Teikyo University School of Medicine, Tokyo, Japan; Departments of Radiology, Teikyo University School of Medicine, Tokyo, Japan; Department of Urology, Juntendo University, Graduate School of Medicine, Tokyo, Japan.

Reference: Prostate Int. 2014 Dec;2(4):188-95.
doi: 10.12954/PI.14067


PubMed Abstract
PMID: 25599075

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