Association between changes in suspicious prostate lesions on serial MRI examinations and follow-up biopsy results - Abstract

We assessed changes in prostate lesions on serial magnetic resonance imaging (MRI) examinations in predicting biopsy results.

Fifty-five men undergoing two prostate MRI examinations ≥6months apart, followed by targeted biopsy, were included. Two radiologists assessed dominant lesions for an increase in size or suspicion score. Progression on MRI had lower sensitivity (23.5%-35.3%) and higher specificity (76.2%-90.5%) than prostate-specific antigen (PSA) velocity (sensitivity 70.6%, specificity 52.4%) for predicting positive biopsy. Highest accuracy was achieved by PSA velocity (63.6%) for positive biopsy, and by MRI (65.5%-72.7%) for Gleason >6 tumor. Findings support lesion progression on MRI serving as a basis for performing subsequent targeted biopsy.

Written by:
Rosenkrantz AB, Rice SL, Wehrli NE, Deng FM, Taneja SS.   Are you the author?
Department of Radiology, NYU Langone Medical Center, New York, NY, USA; Department of Urology, Division of Urologic Oncology, NYU Langone Medical Center, New York, NY, USA.  

Reference: Clin Imaging. 2014 Oct 16. pii: S0899-7071(14)00230-7.
doi: 10.1016/j.clinimag.2014.08.008

PubMed Abstract
PMID: 25457528 Prostate Cancer Section