Incidental uptake of (18)F-fluorocholine (FCH) in the head or in the neck of patients with prostate cancer - Abstract

BACKGROUND: Positron emission tomography-computed tomography (PET/CT) with 18F-fluorocholine (FCH) is routinely performed in patients with prostate cancer.

In this clinical context, foci of FCH uptake in the head or in the neck were considered as incidentalomas, except for those suggestive of multiple bone metastases.

RESULTS: In 8 patients the incidental focus corresponded to a benign tumour. The standard of truth was histology in two cases, correlative imaging with MRI in four cases, 99mTc-SestaMIBI scintigraphy, ultrasonography and biochemistry in one case and biochemistry including PTH assay in one case. The final diagnosis of benign tumours consisted in 3 pituitary adenomas, 2 meningiomas, 2 hyperfunctioning parathyroid glands and 1 thyroid adenoma. Malignancy was proven histologically in 2 other patients: 1 papillary carcinoma of the thyroid and 1 cerebellar metastasis.

CONCLUSIONS: To the best of our knowledge, FCH uptake by pituitary adenomas or hyperfunctioning parathyroid glands has never been described previously. We thus discuss whether there might be a future indication for FCH PET/CT when one such tumour is already known or suspected: to detect a residual or recurrent pituitary adenoma after surgery, to guide surgery or radiotherapy of a meningioma or to localise a hyperfunctioning parathyroid gland. In these potential indications, comparative studies with reference PET tracers or with 99mTc-sestaMIBI in case of hyperparathyroidism could be undertaken.

Written by:
Hodolic M, Huchet V, Balogova S, Michaud L, Kerrou K, Nataf V, Cimitan M, Fettich J, Talbot JN.   Are you the author?
Department for nuclear medicine, University Medical Centre, Ljubljana, Slovenia; Médecine nucléaire, Hôpital Tenon, AP-HP, Paris, France; Comenius University, Bratislava, Slovakia; Université Pierre et Marie Curie, Paris, France; Radiopharmacie, Hôpital Tenon, AP-HP, Paris, France; Nuclear Medicine Unit, National Cancer Institute CRO IRCCS, Aviano, Italy.

Reference: Radiol Oncol. 2014 Jul 10;48(3):228-34.
doi: 10.2478/raon-2013-0075

PubMed Abstract
PMID: 25177236 Prostate Cancer Section