Cutaneous metastasis of prostate carcinoma treated with radiotherapy: A case presentation - Abstract

BACKGROUND: Prostate cancer is a commonly diagnosed and treated malignancy, although it rarely presents with cutaneous metastases.

In this case presentation, we describe the diagnosis and treatment with radiotherapy of a patient who presented with cutaneous metastases on his chest wall secondary to prostate cancer.

CASE PRESENTATION: In 2006, a 73-year-old Caucasian gentleman with metastatic castration resistant prostate cancer treated with mitoxantrone and prednisolone presented with cutaneous nodules on his chest wall. A punch biopsy diagnosed cutaneous metastases, with histological confirmation with positive staining for cytokeratin, PSA (prostate specific antigen) and PAP (prostatic acid phosphatise). Systemic treatment was ceased due to progressive disease; radiotherapy was used to treat these nodules with a durable clinical response. The patient died five months after initial diagnosis of cutaneous metastases.

CONCLUSIONS: In this report, a rare metastatic manifestation of a common malignancy is presented. Whilst dermal metastases carries a poor prognosis from reported literature, this is the first report of radiotherapy providing a durable clinical response with relief from bleeding and pain.

Written by:
Mak G, Chin M, Nahar N, De Souza P.   Are you the author?
Prince of Wales Hospital; Prince of Wales Clinical School, University of New South Wales, Sydney, Australia.  

Reference: BMC Res Notes. 2014 Aug 8;7:505.
doi: 10.1186/1756-0500-7-505

PubMed Abstract
PMID: 25103825 Prostate Cancer Section