The national burden of infections after prostate biopsy in England and Wales: A wake-up call for better prevention - Abstract

Transrectal ultrasound-guided needle biopsies (TGBs) are the mainstay of prostate cancer diagnosis.

An average of 72 500 TGBs were performed in England and Wales in 2008. Current guidelines recommend fluoroquinolone prophylaxis for TGBs. However, emerging fluoroquinolone resistance has led to increased frequency and morbidity due to post-TGB infections. Following TGB, 2.15%-3.6% of patients are readmitted with infective complications. We estimate readmissions result in 25 745-37 062 bed days at an annual cost of £7.7-11.1 million in England and Wales. Clearly, an increase in post-TGB infections with resistant organisms has a profound clinical and economic impact. We suggest alternative approaches to prophylaxis to reduce post-TGB infections. These include prophylaxis based on local antibiotic resistance surveillance and targeted prophylaxis based on antibiograms of coliforms detected in pre-biopsy rectal swabs. Other strategies include selective prostate-specific antigen (PSA) screening and the use of biomarkers like prostate cancer antigen 3 (PCA3) to reduce the number of TGBs. Furthermore, transperineal biopsy has been shown to be associated with fewer infections.

Written by:
Batura D, Gopal Rao G.   Are you the author?
Department of Urology, Northwick Park Hospital, Watford Road, London HA1 3UJ, UK.

Reference: J Antimicrob Chemother. 2012 Oct 9. Epub ahead of print.
doi: 10.1093/jac/dks401

PubMed Abstract
PMID: 23047808 Prostate Cancer Section