BACKGROUND:Statins are a common medication for cholesterol control that may also have effects on cancer-related pathways.
The evidence of an association between statins and prostate cancer risk remains ambiguous.
METHODS:We examined statin use in a prospective cohort of 5069 elderly US men and the risk of incident total, low/high stage, and low/high grade prostate cancer diagnosed between 2000-2008. We used multivariate logistic regression models to estimate relative risks and 95% confidence intervals, adjusting for demographic and lifestyle characteristics.
RESULTS:There was no evidence of an association between statin use and any of the prostate cancer endpoints (total, low/high stage, low/high grade prostate cancer), adjusting for age, study site, race, body mass index, marital status, family history of prostate cancer, number of comorbidities, physical activity, and smoking history.
CONCLUSIONS: In this study of elderly US men, we observed a null association between statin use and risk of prostate cancer.
Chan JM, Harrison SL, Bauer SR, Daniels NA, Wilt TJ, Shannon J, Bauer DC. Are you the author?
Dept of Epidemiology & Biostatistics and Urology, University of California San Francisco, MC 3110, 1450 3rd Street, PO Box 589001, San Francisco, CA, 94158-9001, United States.
Reference: Cancer Epidemiol Biomarkers Prev. 2012 Aug 9. Epub ahead of print.