Statin use and risk of prostate cancer in the prospective Osteoporotic Fractures in Men (MrOS) Study - Abstract

BACKGROUND:Statins are a common medication for cholesterol control that may also have effects on cancer-related pathways.

The evidence of an association between statins and prostate cancer risk remains ambiguous.

METHODS:We examined statin use in a prospective cohort of 5069 elderly US men and the risk of incident total, low/high stage, and low/high grade prostate cancer diagnosed between 2000-2008. We used multivariate logistic regression models to estimate relative risks and 95% confidence intervals, adjusting for demographic and lifestyle characteristics.

RESULTS:There was no evidence of an association between statin use and any of the prostate cancer endpoints (total, low/high stage, low/high grade prostate cancer), adjusting for age, study site, race, body mass index, marital status, family history of prostate cancer, number of comorbidities, physical activity, and smoking history.

CONCLUSIONS: In this study of elderly US men, we observed a null association between statin use and risk of prostate cancer.

Written by:
Chan JM, Harrison SL, Bauer SR, Daniels NA, Wilt TJ, Shannon J, Bauer DC.   Are you the author?
Dept of Epidemiology & Biostatistics and Urology, University of California San Francisco, MC 3110, 1450 3rd Street, PO Box 589001, San Francisco, CA, 94158-9001, United States.

Reference: Cancer Epidemiol Biomarkers Prev. 2012 Aug 9. Epub ahead of print.
doi: 10.1158/1055-9965.EPI-12-0816

PubMed Abstract
PMID: 22879205 Prostate Cancer Section