GU Cancers Symposium 2012 - Empiric antibiotics for an elevated PSA: A randomized, prospective multiinstitutional trial - Session Highlights

SAN FRANCISCO, CA, USA ( - Researchers from six medical centers investigated the empiric use of the antibiotic (ciprofloxacin 500 mg given twice daily) to treat 77 asymptomatic males with newly elevated PSA (>2.5 ng/ml) undergoing their first prostate biopsy.

The mean age of this cohort was 60.6. The control group (n=39) received no antibiotic and had a mean baseline and pre-biopsy PSA of 6.5 and 6.9 respectively. In the group receiving the antibiotic (n=38), the mean baseline and pre-biopsy (post antibiotic) PSA were 7.6 and 8.5 ng/ml respectively. Prostate cancer was detected in 36 (47%) men (detection rates did not differ between males with increasing or decreasing PSAs).

Overall, researchers concluded the empiric use of antibiotics for this patient cohort did not demonstrate a clinical benefit.


Presented by Michael Christopher Large,1 et al. at the 2012 Genitourinary Cancers Symposium - February 2 - 4, 2012 - San Francisco Marriott Marquis - San Francisco, California
1University of Chicago Hospitals, Chicago, IL, Wake Forest U Baptist Hospital, Forsyth Medical center, Rabin Medical Center, Northwestern Medical Center, Penn State College of Medicine

Reported for UroToday by Karen Roberts, Medical Writer



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