TRP channels in prostate cancer: The good, the bad and the ugly? - Abstract

Inserm U1003, Equipe labellisée par la Ligue Nationale contre le cancer, Villeneuve d'Ascq, France.

Université des Sciences et Technologies de Lille (USTL), Villeneuve d'Ascq, France.



During the last decade, transient receptor potential (TRP) channels emerge as key proteins in central mechanisms of the carcinogenesis such as cell proliferation, apoptosis and migration. Initial studies showed that expression profile of some TRP channels, notably TRP melastatin 8 (TRPM8), TRP vanilloid 6 (TRPV6),TRP canonical (TRPC6) and TRPV2, is changing during the development and the progression of prostate cancer towards the hormone-refractory stages. The link between the change in expression levels and the functional role of these channels in prostate cancer is step by step being elucidated. These recent advances are here described and discussed.

Written by:
Gkika D, Prevarskaya N.   Are you the author?

Reference: Asian J Androl. 2011 May 30. Epub ahead of print.
doi: 10.1038/aja.2011.18

PubMed Abstract
PMID: 21623387 Prostate Cancer Section