Docetaxel plus prednisone in patients with metastatic hormone-refractory prostate cancer: An Italian clinical experience - Abstract

Oncology Department, Medical Oncology Unit, Policlinico Universitario, University of Palermo, Italy.


We investigated the efficacy of docetaxel plus prednisone in Italian patients with metastatic hormone-refractory prostate cancer (mHRPC).

Twenty four patients with mHRPC received docetaxel 75 mg/m2 every 3 weeks plus prednisone 5 mg twice daily for up to six cycles. The primary endpoint was efficacy measured by a reduction in serum prostate specific antigen (PSA) levels and measurable disease. Evaluation of toxicity, quality of life and reduction of pain were secondary endpoints.

PSA response was seen in 18 patients (75%). We observed a partial response in 2 patients (8.3%), stable disease in 10 patients (41.7%), and disease progression in 12 patients (50%). Severe neutropenia was reported in 12.5% of patients.

Treatment with docetaxel every three weeks is an effective and well tolerated therapeutic option in patients with mHRPC.

Written by:
Cicero G, De Luca R.   Are you the author?

Reference: Eur Rev Med Pharmacol Sci. 2011 Mar;15(3):325-31.

PubMed Abstract
PMID: 21528780 Prostate Cancer Section