Glickman Urological and Kidney Institute, Cleveland Clinic, Cleveland, OH, USA.
To assess the rationale, efficacy, and morbidity of various methods of achieving focal prostatic ablation. To determine the current role of focal therapy in the management of localized prostate cancer.
We performed a literature review of focal therapy in prostate cancer, with an emphasis on more established methods such as cryoablation and high-intensity focused ultrasound.
Focal ablative methods allow targeted destruction of prostatic tissue while limiting the morbidity associated with whole-gland therapy. Local cancer control after focal therapy appears promising but does not approach that of established whole-gland therapies. Until we have the ability to identify patients reliably with truly focal disease and predict their natural history, focal therapy cannot be considered to be the definitive therapy for localized prostate cancer.
Written by:
Nguyen CT, Jones JS.
Are you the author?
Reference: BJU Int. 2011 Jan 11. Epub ahead of print.
doi: 10.1111/j.1464-410X.2010.09975.x
PubMed Abstract
PMID: 21223478
UroToday.com Prostate Cancer Section
