Men on active surveillance (AS), with prostate cancer, are very interested in dietary strategies that could improve their symptoms and help prevent progression of their disease. In this real-world trial involving 208 men, intake of phytochemical-rich food capsules helped slow prostate-specific antigen (PSA) progression significantly, and improved urinary symptoms and erectile function.
What was novel about this study was that men randomised to take an additional blend of five Lactobacillus probiotics had a further three-fold slowing of PSA progression as well as reduction of inflammation. Currently, nearly 50% of men opt out of AS within 5 yr. If confirmed with further follow-up, these dietary interventions, alongside other lifestyle manoeuvres, could reassure men to remain on AS, and hence avoid the risks of radiotherapy, hormones, or surgery.
European urology oncology. 2025 Oct 27 [Epub ahead of print]
Robert J Thomas, Stacey A Kenfield, Madeleine Williams, Robert U Newton, Jeffrey Aldous, Anita Mitra, Zahoor Fazili
Addenbrooke's Hospital, Cambridge, UK; Bedford Hospital, Bedford, UK; Cambridge University Hospitals, Cambridge, UK; NHS Trusts, UK. Electronic address: ., Department of Urology, University of California, San Francisco (UCSF), San Francisco, CA, USA; Department of Epidemiology & Biostatistics, University of California, San Francisco (UCSF), San Francisco, CA, USA., The Primrose Research Unit, Bedford Hospital, Bedford, UK., Exercise Medicine Research Institute, Edith Cowan University, Perth, Western Australia, Australia., Institute for Sport and Physical Activity Research (ISPAR), University of Bedfordshire, Bedford, UK., University College London Hospital, London, UK., Bedfordshire Hospital Trusts, The Department of Urology, Bedford Hospital, Bedford, UK.
PubMed http://www.ncbi.nlm.nih.gov/pubmed/41152052