Prostate cancer incidence is highest for Black men of the African diaspora in the United States and Caribbean. Recent changes in recommendations for prostate cancer screening have been shown to decrease overall prostate cancer incidence and increase the likelihood of late stage disease. However, it is unclear how trends in prostate cancer characteristics among high risk Black men differ by geographic region during the changes in screening recommendations.
In this study, we used population-based prostate cancer registry data to describe age-adjusted prostate cancer incidence trends from 2008 to 2015 among Black men from six geographic regions. We obtained data on incident Black prostate cancer patients from six cancer registries (in the United States: Florida, Alabama, Pennsylvania, and New York; and in the Caribbean: Guadeloupe and Martinique). After age standardization, we used descriptive analyses to compare the demographics and tumor characteristics by cancer registry site. The Joinpoint regression program was used to compare the trends in incidence by site.
A total of 59,246 men were analyzed. We found the highest incidence rates (per 100,000) for prostate cancer in the Caribbean countries (181.99 in Martinique and 176.62 in Guadeloupe) and New York state (178.74). Incidence trends decreased significantly over time at all sites except Martinique, which also showed significantly increasing rates of late stage (III/IV) and Gleason score 7+ tumors.
We observed significant differences in prostate cancer incidence trends among Black men after major changes prostate screening recommendations. Future studies will examine the factors that differentially influence prostate cancer trends among the African diaspora.
The Prostate. 2023 May 27 [Epub ahead of print]
Charnita Zeigler-Johnson, Alicia C McDonald, Paulo Pinheiro, Shannon Lynch, Emanuela Taioli, Shivam Joshi, Naomi Alpert, Jacqueline Baudin, Clarisse Joachim, Jacqueline Deloumeaux, JoAnn Oliver, Bernard Bhakkan-Mambir, Murielle Beaubrun-Renard, Angel G Ortiz, Camille Ragin
Department of Medical Oncology, Division of Population Science, Thomas Jefferson University, Philadelphia, Pennsylvania, USA., Department of Public Health Sciences, College of Medicine, Pennsylvania State University, Hershey, Pennsylvania, USA., Department of Public Health Sciences, University of Miami, Miami, Florida, USA., Fox Chase Cancer Center, Philadelphia, Pennsylvania, USA., Mount Sinai, New York City, New York, USA., Unité Fonctionnelle Recherche en Cancérologie UF3596, Centre Hospitalier Universitaire de Martinique, Fort-de-France, Martinique., Registre Général des cancers de la Martinique UF1441, Centre Hospitalier Universitaire de Martinique, Fort-de-France, Martinique., Registre Général des cancers de la Guadeloupe, Centre Hospitalier Universitaire de la Guadeloupe, Pointe-a-Pitre, Guadeloupe., Capstone College of Nursing, University of Alabama, Tuscaloosa, Alabama, USA.