Implementing and Evaluating the Impact of BoneRx: A Healthy Bone Prescription for Men with Prostate Cancer Initiating Androgen Deprivation Therapy.

The initiation of Androgen Deprivation Therapy (ADT) results in rapid and profound hypogonadism, resulting in significant bone and muscle loss, increasing the risk for osteoporosis (OP), falls, and fractures. Despite this, there exist very low rates of guideline adherent care regarding bone health in this population. We developed and implemented a healthy bone prescription tool entitled BoneRx to facilitate the uptake of guideline-concordant bone health care into practice and increase patient awareness and promote the uptake of health bone behaviours (HBBs).

We conducted a cross-sectional pre-BoneRx implementation (n = 143) vs. post-implementation (n = 149) cohort study to evaluate the impact on (i) bone health care, patient engagement in HBB, and patient knowledge and health beliefs regarding OP.

There was a significant difference pre- vs. post BoneRx implementation on receipt of baseline BMD (34.7% vs. 59.5%, p < 0.0001) and bone health counselling (32.4% vs. 59.9%, p < 0.0001). More participants in the post-BoneRx implementation cohort reported taking vitamin D supplements 57% vs. 81% (p < 0.001) and calcium supplements 39% vs. 61% (p < 0.001). Physical activity levels also significantly increased (p = 0.021). No differences were detected in OP knowledge or feelings of OP susceptibility, seriousness, or health motivation.

BoneRx is a simple, cost-effective, and acceptable strategy that could improve the care of PCa survivors receiving ADT.

Journal of clinical medicine. 2022 May 11*** epublish ***

Jennifer M Jones, Derek S Tsang, Shiyu Zheng, Ariel Yeheskel, Charles N Catton, Angela M Cheung, Robert Hamilton, Shabbir M H Alibhai

Cancer Rehabilitation and Survivorship Program, Department of Supportive Care, Princess Margaret Cancer Centre, 200 Elizabeth Street, Toronto, ON M5G 2C4, Canada., Raditation Medicine Program, Princess Margaret Cancer Centre, 610 University Av., Toronto, ON M5G 2M9, Canada., Faculty of Medicine, University of Toronto, 1 King's College Cir, Toronto, ON M5S 1A8, Canada., Osteoporosis Program and Centre of Excellence in Skeletal Health Assessment, University Health Network, 200 Elizabeth Street, 7EN-Rm 221, Toronto, ON M5G 2C4, Canada., Department of Surgery (Urology), University of Toronto, 610 University Av., Toronto, ON M5G 2M9, Canada., Department of Medicine, University Health Network, 200 Elizabeth Street, Toronto, ON M5G 2C4, Canada.

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