Here, we evaluated 95 patients with biochemically recurrent prostate cancer who had 68Ga-RM2 PET/MRI. Three different readers looked at images and measured the uptake level (SUVmax and SUVmean) in 24 different organs by drawing a 2D region of interest in the organ itself. An arbitrary scale was used and uptake in various tissues was classified into 4 categories. SUVmean was also correlated to some factors such as BMI, age, injected dose and uptake time, to look for any possible influence of these factors on the uptake. We found out that age and BMI influenced the uptake of certain organs. However, the influence of BMI decreased consistently when the lean body mass was used to normalize the SUVs calculation instead of body weight. By improving the understanding of 68Ga-RM2 biological behavior, this atlas will help increase the investigators’ confidence when using GRPR-targeting radiopharmaceuticals in various indication.
Lucia Baratto, MD, Postdoctoral Research Fellow, Division of Nuclear Medicine and Molecular Imaging, Department of Radiology, Stanford University Medical Center, Stanford, California, USA
Andrei H. Iagaru, MD, FACNM, Professor of Radiology - Nuclear Medicine, Chief, Division of Nuclear Medicine and Molecular Imaging, Director, Nuclear Medicine Residency Program, Co-Director, PET-MRI Research Program, Stanford University, Stanford, California, USA
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