To investigate the risk factors contributing to multiple lymph node invasion (LNI) in patients with prostate cancer (PCa) undergoing extended pelvic lymph node dissection (ePLND) during robot assisted radical prostatectomy (RARP).
211 patients who underwent RARP and ePNLD from June 2013 to March 2017 were classified according to lymph node status in the surgical specimen (absent, single or multiple). Risk factors of LNI were evaluated by the multinomial logistic regression model. A receiver operating characteristic (ROC) curve and area under the curve (AUC) were used to assess the efficacy of factors and model evaluation.
On multivariate analysis, the risk of multiple LNI, was independently increased by BMI (odds ratio, OR = 1.194; P = 0.026) and PSA (OR = 1.089; P = 0.014) when compared to patients without LNI. ROC curves indicated that both BMI (AUC = 0.702) and PSA (AUC = 0.732) had fair discrimination power. For each unit of increase in PSA, the odds of multiple lymph node invasion increased by 8.9% and for each unit increase of BMI, the odds of multiple LNI increased by 19.4%.
The risk of multiple LNI was independently predicted by PSA and BMI with fair discrimination power.
Minerva urologica e nefrologica = The Italian journal of urology and nephrology. 2019 Jun 21 [Epub ahead of print]
Antonio B Porcaro, Alessandro Tafuri, Marco Sebben, Tania Processali, Marco Pirozzi, Nelia Amigoni, Riccardo Rizzetto, Aliasger Shakir, Giovanni E Cacciamani, Matteo Brunelli, Salvatore Siracusano, Maria Angela Cerruto, Walter Artibani
Department of Urology, Azienda Ospedaliera Universitaria Integrata Verona, University of Verona, Verona, Italy - ., Department of Urology, Azienda Ospedaliera Universitaria Integrata Verona, University of Verona, Verona, Italy., Catherine & Joseph Aresty Department of Urology, SC Institute of Urology, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA., Department of Pathology, Azienda Ospedaliera Universitaria Integrata, University of Verona, Verona, Italy.