Three new gold(I)-coumarin-based trackable therapeutic complexes and two non-trackable analogues have been synthesized and fully characterized. They all display antiproliferative properties on several types of cancer cell lines including colon, breast, and prostate. Two complexes displayed significant anti-inflammatory effect, while one displayed a pro-inflammatory behaviour - highlighting the impact of the position of the fluorophore on the caffeine scaffold. Additionnally, the three coumarin derivatives could be vizualized in vitro by two-photons microscopy.
ChemMedChem. 2018 Sep 11 [Epub ahead of print]
Audrey Trommenschlager, Florian Chotard, Benoît Bertrand, Souheila Amor, Philippe Richard, Ali Bettaïeb, Catherine Paul, Jean-Louis Connat, Pierre Le Gendre, Ewen Bodio
FRANCE., Burgundy University, Institut de Chimie Moleculaire de l'Universite de Bourgogne - UMR CNRS 6302, 9 avenue Alain Savary, BP 47870, 21078, Dijon, FRANCE.