The National Research Council (CNR) prostate cancer monitoring project in Italy (Pros-IT CNR) is an observational, prospective, ongoing, multicentre study aiming to monitor a sample of Italian males diagnosed as new cases of prostate cancer. The present study aims to present data on the quality of life at time prostate cancer is diagnosed.
One thousand seven hundred five patients were enrolled. Quality of life is evaluated at the time cancer was diagnosed and at subsequent assessments via the Italian version of the University of California Los Angeles-Prostate Cancer Index (UCLA-PCI) and the Short Form Health Survey (SF-12).
At diagnosis, lower scores on the physical component of the SF-12 were associated to older ages, obesity and the presence of 3+ moderate/severe comorbidities. Lower scores on the mental component were associated to younger ages, the presence of 3+ moderate/severe comorbidities and a T-score higher than one. Urinary and bowel functions according to UCLA-PCI were generally good. Almost 5% of the sample reported using at least one safety pad daily to control urinary loss; less than 3% reported moderate/severe problems attributable to bowel functions, and sexual function was a moderate/severe problem for 26.7%. Diabetes, 3+ moderate/severe comorbidities, T2 or T3-T4 categories and a Gleason score of eight or more were significantly associated with lower sexual function scores at diagnosis.
Data collected by the Pros-IT CNR study have clarified the baseline status of newly diagnosed prostate cancer patients. A comprehensive assessment of quality of life will allow to objectively evaluate outcomes of different profile of care.
Health and quality of life outcomes. 2018 Jun 13*** epublish ***
Angelo Porreca, Marianna Noale, Walter Artibani, Pier Francesco Bassi, Filippo Bertoni, Sergio Bracarda, Giario Natale Conti, Renzo Corvò, Mauro Gacci, Pierpaolo Graziotti, Stefano Maria Magrini, Vincenzo Mirone, Rodolfo Montironi, Giovanni Muto, Stefano Pecoraro, Umberto Ricardi, Elvio Russi, Andrea Tubaro, Vittorina Zagonel, Gaetano Crepaldi, Stefania Maggi, Pros-IT CNR study group
Policlinico di Abano Terme, Padova, Italy., National Research Council (CNR), Neuroscience Institute, Aging Branch, Via Giustiniani 2, 35128, Padova, Italy. ., Azienda Ospedaliera Universitaria Integrata di Verona, Verona, Italy., Policlinico Universitario A. Gemelli, Università Cattolica del Sacro Cuore di Milano - Sede di Roma, Roma, Italy., Prostate Group of AIRO - Italian Association for Radiation Oncology, Milano, Italy., Ospedale San Donato, Arezzo, Italy., Ospedale Sant'Anna, Como, Italy., IRCCS San Martino-IST, Genova, Italy., Università di Firenze, Firenze, Italy., Ospedale S. Giuseppe, Milano, Italy., Università di Brescia, Brescia, Italy., Università degli Studi di Napoli Federico II, Napoli, Italy., Università Politecnica delle Marche, Ancona, Italy., Università Campus Bio-medico, Roma, Italy., Malzoni Center, Avellino, Italy., Università di Torino, Torino, Italy., A.O. S. Croce e Carle, Cuneo, Italy., Ospedale Sant'Andrea, Roma, Italy., Istituto Oncologico Veneto IOV-IRCCS, Padova, Italy.