Secondary NK/T cell lymphoma after radiotherapy for non-HPV-related squamous cell carcinoma of the penis: an early warning event and literature review.

Squamous cell carcinoma is the most common malignant tumor of the penis. The new World Health Organization (WHO) classifies it into two types: non-HPV-related and HPV-related. There is a certain proportion of recurrence and metastasis after the first operation on the tumor. Radiotherapy is one of the effective methods to improve prognosis, but there is a risk of secondary primary malignant tumor. Primary NK/T cell lymphoma of the penis is rare, and secondary primary NK/T cell lymphoma of penile stump after radiotherapy for penile cancer has not been reported. Here we report a case of a 75-year-old man who was diagnosed with primary non-HPV-related squamous cell carcinoma of the penis five years after the operation of gastric adenocarcinoma. One year after the first penile operation, penile cancer recurred with multiple metastases in the left inguinal lymph nodes, and radiotherapy was performed after re-operation. Secondary primary penile NK/T cell lymphoma was induced 16 months after radiotherapy. Secondary lymphoma after radiotherapy for penile cancer is an accidental event, and the efficacy and risk of postoperative radiotherapy need to be further evaluated.

International journal of clinical and experimental pathology. 2020 Aug 01*** epublish ***

Di Sun, Ping Yang, Li Zhang, Lei Jiang, Guohua Yu

Department of Pathology, Yantai Yuhuangding Hospital of Qingdao University Yantai, China.