Clear cell adenocarcinoma of the urethra with inguinal lymph node metastases: A rare case report and review of literature

Urethral cancer is a rare malignancy with urothelial subtype being the most common followed by adenocarcinoma. In women, the usual presentation is urinary retention and hematuria. Clear cell variety of adenocarcinoma is a rarer entity which usually has a better prognosis than other variants. Lymph node metastasis is seen in about 30% of urethral cancers. Histopathological differential diagnosis includes Skene gland carcinoma and nephrogenic adenoma. Herein, we present a 58-year-old female patient who presented for evaluation of lymph node mass in the inguinal region. The detailed evaluation revealed clear cell adenocarcinoma of the urethra as the primary with lymph node metastasis.

Journal of cancer research and therapeutics. 0000 Jan [Epub]

Varuna Mallya, Ashwin Mallya, J Gayathri

Department of Pathology, Dr. B. R. Ambedkar Medical College, Bengaluru, Karnataka, India., Department of Urology, Institute of Nephrourology, Bengaluru, Karnataka, India.