We studied epidermal growth factor receptor (EGFR) expression profile in Urothelial Bladder carcinoma (UBC) which is a complex and heterogeneous disease with a large spectrum of histological aspects and deadly potential.
Using immunohistochemistry (IHC), All GI tumors and pTa cases showed a low expression profile of EGFR. However, we note that when the stage of disease is advanced, tumors over-express EGFR. Indeed, 5% and 25% of GII and GIII tumors over-expressed EGFR, respectively. Further, 0% of pTa, 9,5% of pT1, 15% of pT2, 50% of pT3, and 90% of pT4 tumors were shown to be high EGFR expression (HEE). Moreover, we found a statistically significant correlation between the EGFR over-expression and grade and stage (p<0.05). Thus, EGFR over-expression could be a potential prognostic marker to predict poor outcome in Tunisian patients with UBC.
Journal of immunoassay & immunochemistry. 2016 Feb 26 [Epub ahead of print]
Arfaoui Toumi Amira, S Mejri, R Belhaj, W Karkni, M Chebil, S Rammeh
a Department of Pathology , Charles Nicolle University Hospital , Tunis , Tunisia., a Department of Pathology , Charles Nicolle University Hospital , Tunis , Tunisia., a Department of Pathology , Charles Nicolle University Hospital , Tunis , Tunisia., b Department of Urology , Charles Nicolle University Hospital , Tunis , Tunisia., b Department of Urology , Charles Nicolle University Hospital , Tunis , Tunisia., a Department of Pathology , Charles Nicolle University Hospital , Tunis , Tunisia.