Discoidin domain receptor (DDR) is a new member of the receptor tyrosine kinase family. There are two isoforms of discoidin domain receptor (DDR), DDR1 and DDR2. These receptors play a major role in the adhesion, motility and cell proliferation.
Due to the important role of DDR2 in the development of tumor extension, this receptor is pivotal in the field of carcinogenesis. The aim of this study was to investigate the mRNA and protein expression of DDR2, in the malignant, benign prostatic hyperplasia (BPH) and normal tissues of patients with prostate cancer. In this study the gene and protein expression of DDR2 in adjacent normal (n=40), BPH (n=40), and malignant (n=40) prostate tissue were measured using real-time PCR and Western blotting. Then, the correlation of DDR2 gene and protein expression with prognostic factors such as age, tumor grade, tumor stage, lymph node involvement, and serum prostate-specific antigen (PSA) concentration were evaluated. The relative mRNA and protein expression level of DDR2 in malignant and benign prostate tissue was significantly higher than those of adjacent normal tissues (P
Research in pharmaceutical sciences. 0000 [Epub]
Mitra Azemikhah, Hamidreza Ahmadi Ashtiani, Mahmoud Aghaei, Hosein Rastegar
Department of Biology, science and research branch, Islamic Azad University, Tehran, I. R. Iran. , Islamic Azad University, pharmaceutical sciences branch, Tehran, I. R. Iran. , Department of Clinical Biochemistry and Isfahan Pharmaceutical Sciences Research Center, School of Pharmacy and Pharmaceutical Sciences Isfahan, I. R. Iran. , Food and Drug Control Laboratory and Research Center, Tehran, I. R. Iran.