Long non-coding RNAs (lncRNAs) UCA1 have been shown to paly an important regulatory roles in cancer biology, and UCA1 dysfunction is related to TNM stage, metastasis and postoperative survival in several cancers.
However, the biological role and clinical significance of UCA1 in the carcinogenesis of prostate cancer (PC) remain largely unclear. Herein, we found that UCA1 was abnormally upregulated in tumor tissues from PC patients, and patients with high UCA1 levels had a significantly poorer prognosis. Intriguingly, the mRNA and protein levels of KLF4 were significantly increased in tumor tissues, which was highly correlated to UCA1 levels. Moreover, UCA1 depletion inhibited the growth and induced apoptosis in PC3 and LNCaP cell lines. In addition, UCA1 loss-of-function could decrease KLF4 expression, subsequently, the downregulation of KRT6 and KRT13. Taken together, our study indicated that UCA1 had a crucial role in the tumorigenesis of PC. Moreover, UCA1 loss-of-function inhibited cell proliferation and induced cell apoptosis, at least partially, through inactivation KLF4-KRT6/13 cascade.
International journal of clinical and experimental medicine. 2015 Aug 15*** epublish ***
Xin-Yu Na, Zong-Yuan Liu, Peng-Peng Ren, Rui Yu, Xiao-Song Shang
Department of Urology Surgery, Longsai Hospital Ningbo 315200, China. , Department of Urology Surgery, Longsai Hospital Ningbo 315200, China. , Department of Urology Surgery, Longsai Hospital Ningbo 315200, China. , Medical College of Ningbo University Ningbo 315211, China. , Department of Urology Surgery, Longsai Hospital Ningbo 315200, China.