Early prostate cancer antigen 2 (EPCA-2), a kind of nuclear matrix protein, may relate to prostate cancer. However, the association of EPCA-2 level in serum with prostate diseases has not been clarified in Chinese Han population.
EPCA-2 and prostate-specific antigen (PSA) levels in serum were detected by enzyme linked immunosorbent assay in 116 patients with prostate cancer (PCa), 342 patients with benign prostatic hyperplasia (BPH), and 174 healthy controls (Control) in Chinese population. Associations of serum EPCA-2 and PSA level with prostate diseases were analyzed by ANOVA. Comparison of diagnostic effect for prostate cancer between EPCA-2 and PSA was evaluated by Receiver Operator Curve, Chi-square test, and others.
Serum EPCA-2 and PSA levels in PCa group were significantly higher than BPH and Control group (EPCA-2: F=200. 05, P
Serum EPCA-2 could be used as a potential serological marker to diagnose prostate cancer in Chinese Han population, which was more specific than PSA and did not associate with pathological grades of prostate cancer.
International journal of clinical and experimental pathology. 2015 Aug 01*** epublish ***
Lei Wang, Ling Ma, Xinli Wang, Bing Li, Shan Guo, Qingdong Qiao
Department of Urology I, Xinxiang Central Hospital Xinxiang, Henan, China ; Department of Urology, Chinese PLA General Hospital, Medical School of Chinese PLA Beijing, China. , Department of Urology II, Xinxiang Central Hospital Xinxiang, Henan, China. , Department of Urology I, Xinxiang Central Hospital Xinxiang, Henan, China. , Department of Inspection, Xinxiang Central Hospital Xinxiang, Henan, China. , Department of Inspection, Xinxiang Central Hospital Xinxiang, Henan, China. , Department of Urology I, Xinxiang Central Hospital Xinxiang, Henan, China.