Using a porcine model, 9 out of 1o cystoscopically-insert Uriprene stents had completely degraded within the 4-week study period. In comparison to a standard biostable stent, radiologic imaging demonstrated equivalent drainage throughout and less hydronephrosis in Uriprene-stented kidneys two weeks after placement. In addition, hematologic and urinalysis parameters were not affected by the placement of the stents. Pathologic inspection demonstrated less stent-related bullous edema and bladder mucosal thickening as well as less histologic inflammation.
Although further follow-up trials are necessary, this retrogradely degrading ureteral stent may be able to provide effective drainage while minimizing stent-related morbidity.
Presented by Ben Chew, et al. at the American Urological Association (AUA) Annual Meeting - May 14 - 19, 2011 - Walter E. Washington Convention Center, Washington, DC USA
Reported for UroToday by Jason Y. Lee MD, FRCSC, Department of Urology, University of California, Irvine.
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