Validation of a protein panel for the non-invasive detection of recurrent non-muscle invasive bladder cancer

50-70% of patients with non-muscle invasive bladder cancer (NMIBC) experience relapse of disease.

To establish a panel of protein biomarkers incorporated in a multiplexed microarray (BCa chip) and a classifier for diagnosing recurrent NMIBC.

Urine samples from 45 patients were tested. Diagnostic performance was evaluated by receiver operating characteristic (ROC) analysis.

A multi biomarker panel (ECadh, IL8, MMP9, EN2, VEGF, past recurrences, BCG therapies, stage at diagnosis) was identified yielding an area under the curve of 0.96.

This biomarker panel represents a potential diagnostic tool for non-invasive diagnosis of recurrent NMIBC.

Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals. 2016 Dec 23 [Epub ahead of print]

Selma Gogalic, Ursula Sauer, Sara Doppler, Andreas Heinzel, Paul Perco, Arno Lukas, Guy Simpson, Hardev Pandha, Andras Horvath, Claudia Preininger

a AIT Austrian Institute of Technology GmbH , Konrad-Lorenz-Straße 24, 3430 Tulln , Austria., b emergentec biodevelopment GmbH , Gersthofer Strasse 29-31, 11080 Vienna , Austria., c Oncology, Faculty of Health and Medical Sciences , Leggett Building, University of Surrey , Surrey GU2 7WG , UK.