The human papilloma virus (HPV) is a carcinogen known for its strong association with cervical cancers and cervical lesions. It is also known to be associated with a variety of squamous cell carcinomas in other areas, such as the penis, vulva, anus and head and neck. However, the association with urothelial carcinoma remains controversial. Here, we report a case of urothelial carcinoma with squamous differentiation associated with HPV-6/HPV-11.
This is a case of a 70 year old man who presented with nocturia and pressure during urination. During the TURP procedure for what was clinically thought to be benign prostate hyperplasia with pathologic diagnosis as prostate carcinoma, a 2 cm papillary mass was found in the distal penile urethra. The papillary mass was found to be a high grade urothelial carcinoma positive for GATA 3 expression, with focal areas of squamous differentiation. The areas with squamous differentiation demonstrated koilocytic differentiation, which were positive for strong p16 expression. The tumor was found to harbor low risk HPV 6/11 by in situ hybridization.
This study case demonstrates HPV infection with a low risk subtype (HPV 6/11) associated with an urothelial carcinoma with squamous differentiation and condylomatous features.
American journal of clinical and experimental urology. 2016 Jan 28*** epublish ***
Sergei Guma, Remegio Maglantay, Ryan Lau, Rosemary Wieczorek, Jonathan Melamed, Fang-Ming Deng, Ming Zhou, Danil Makarov, Peng Lee, Matthew R Pincus, Zhi-Heng Pei
Department of Pathology, York University School of Medicine New York, NY 10010, USA., Department of Pathology, State University of New York Brooklyn, NY 10010, USA., Department of Pathology, York University School of Medicine New York, NY 10010, USA., Department of Pathology, State University of New YorkBrooklyn, NY 10010, USA; Department of Veterans Affairs New York Harbor Healthcare SystemNew York, NY 10010, USA., Department of Pathology, York University School of Medicine New York, NY 10010, USA., Department of Pathology, York University School of Medicine New York, NY 10010, USA., Department of Pathology, York University School of Medicine New York, NY 10010, USA., Department of Urology, New York University School of Medicine New York, NY 10010, USA., Department of Pathology, York University School of MedicineNew York, NY 10010, USA; Department of Veterans Affairs New York Harbor Healthcare SystemNew York, NY 10010, USA; Department of Urology, New York University School of MedicineNew York, NY 10010, USA., Department of Pathology, State University of New YorkBrooklyn, NY 10010, USA; Department of Veterans Affairs New York Harbor Healthcare SystemNew York, NY 10010, USA., Department of Pathology, York University School of MedicineNew York, NY 10010, USA; Department of Veterans Affairs New York Harbor Healthcare SystemNew York, NY 10010, USA.