To further analyse the relation between coffee, tea and energy drinks and bladder cancer risk, considering dose, duration, and other time-related factors.
A multicentric case-control study on 690 bladder cancer cases and 665 hospital controls was conducted in Italy between 2003 and 2014.
Odds ratios (OR) for bladder cancer were estimated using multiple logistic regression models. Compared with never coffee drinkers, sex, age, and tobacco-adjusted ORs were 1. 28 (95% confidence interval, CI, 0. 85-1. 94) for current drinkers and 1. 69 (95% CI 1. 05-2. 72) for lifetime drinkers of ≥4 cups/day. The corresponding ORs for an increment of one cup/day were 1. 03 (95% CI 0. 96-1. 11) and 1. 07 (95% CI 0. 99-1. 15), respectively. No association was found with duration or age at starting and no significant heterogeneity was found according to age and sex, although a slight increased risk emerged in never smokers. Decaffeinated coffee, tea, cola, and energy drinks were not related with bladder cancer risk.
Our study found no significant relation between coffee and bladder cancer risk after accounting for smoking, although the OR was above unity for high lifetime habit. The lack of dose and duration relationships, however, suggests the absence of a causal relation.
Urology. 2015 Sep 25 [Epub ahead of print]
Federica Turati, Cristina Bosetti, Jerry Polesel, Antonella Zucchetto, Diego Serraino, Maurizio Montella, Massimo Libra, Antonio Galfano, Carlo La Vecchia, Alessandra Tavani
Department of Epidemiology, IRCCS - Istituto di Ricerche Farmacologiche "Mario Negri", Milan, Italy. , Department of Epidemiology, IRCCS - Istituto di Ricerche Farmacologiche "Mario Negri", Milan, Italy. , Unit of Epidemiology and Biostatistics, CRO Aviano National Cancer Institute, IRCCS, Aviano, Italy. , Unit of Epidemiology and Biostatistics, CRO Aviano National Cancer Institute, IRCCS, Aviano, Italy. , Unit of Epidemiology and Biostatistics, CRO Aviano National Cancer Institute, IRCCS, Aviano, Italy. , Unit of Epidemiology, Istituto Tumori "Fondazione Pascale IRCCS", Naples, Italy. , Department of Biomedical Sciences, Università di Catania, Catania, Italy. , Department of Urology, Ospedale Niguarda Ca' Granda, Milan, Italy. , Department of Clinical Sciences and Community Health, Università degli Studi di Milano, Milan, Italy. , Department of Epidemiology, IRCCS - Istituto di Ricerche Farmacologiche "Mario Negri", Milan, Italy.