Heavy Cigarette Smoking and Aggressive Bladder Cancer at Initial Presentation

To identify the impact of smoking intensity on tumor characteristics at time of initial bladder cancer diagnosis.

We retrospectively reviewed our institution's prospective database of patients diagnosed with bladder cancer from 1987 to 2009.

Only patients with urothelial cell carcinoma and recorded tobacco history were included. Patients were stratified by tobacco history into non-smokers, light-smokers (≤30 pack-years), and heavy-smokers (>30 pack-years). An additional analysis was performed looking at patients meeting National Lung Cancer Screening Trial (NLCST) criteria (55-74 year old patients with ≥ 30 pack-years smoking history and

We identified 197 (26. 6%) non-smokers, 251 (33. 9%) light smokers, and 292 (39. 5%) heavy smokers. Males were more likely to be heavy smokers (44. 5% v. 23. 6% p=

Heavy smokers and patients meeting NLCST criteria are more likely to have high-grade tumors with detrusor muscle invasion at initial presentation.

Urology. 2015 Jul 16 [Epub ahead of print]

Eugene J Pietzak, Phillip Mucksavage, Thomas J Guzzo, S Bruce Malkowicz

Division of Urology, Department of Surgery, Hospital of the University of Pennsylvania, Philadelphia, PA. Division of Urology, Department of Surgery, Hospital of the University of Pennsylvania, Philadelphia, PA. , Division of Urology, Department of Surgery, Hospital of the University of Pennsylvania, Philadelphia, PA. , Division of Urology, Department of Surgery, Hospital of the University of Pennsylvania, Philadelphia, PA.

PubMed

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