Second transurethral resection after Ta high-grade bladder tumor: A 4.5-year period at a single university center - Abstract

Purpose: We evaluated the results of second transurethral resections of the bladder (TURB) after pTa high-grade bladder cancer over a 4.5-year period.

Patients and Methods: From July 2007 to December 2011, 2,159 TURBs were performed at our institution, of which 1,143 were initial resections for primary bladder tumor or recurrence. Of these, 142 revealed pTa high-grade bladder cancer, and here we investigated tumor characteristics of initial TURB and results of second resection.

Results: The incidence of pTa high-grade tumor was 12.4% (n = 142). Of 87 patients who underwent a second resection, tumor was found in 36 (41.4%); tumors were multifocal in 25 (69.4%) and < 3 cm in 29 (80.6%). Tumor was detected at the primary site in 38.9%, at other locations in 22.2%, and at both in 38.9%. Histology revealed pTa low-grade in 13 (14.9% of 87), pTa high-grade in 15 (17.2%), and pT1 in 5 (5.7%) patients. No muscle-invasive tumor was detected. A significant association was found for the number of tumors at initial TURB: in patients with tumor at second resection, 55.1% had had multiple tumors at first resection, more than twice those with solitary tumor (23.7%) (0.004).

Conclusions: In our study, Ta high-grade tumors show a relevant rate of persistent tumor at second resection, most of them located at the primary tumor site. As recommended by the American and European clinical guidelines, patients with Ta high-grade tumor should undergo second resection.

Written by:
Lazica DA, Roth S, Brandt AS, Böttcher S, Mathers MJ, Ubrig B.   Are you the author?
Department of Adult and Pediatric Urology, Center for Clinical Research (CCR), University of Witten/Herdecke, HELIOS Hospital, Wuppertal, Germany.

Reference: Urol Int. 2013 Aug 23. Epub ahead of print.
doi: 10.1159/000353089

PubMed Abstract
PMID: 23988813 Bladder Cancer Section