AUA 2011 - Influence of smoking history on bladder cancer patient outcome following radical cystectomy - Session Highlights

WASHINGTON, DC USA ( - Smoking is a major risk factor for development of bladder cancer and is a significant health hazard. The impact of smoking on recovery and survival after radical cystectomy is unclear. The authors looked at 1,185 patients who were found to have,
  1. presence of bladder transitional cell carcinoma without distant metastasis,
  2. minimum 2 year post-cystectomy follow up if patient was alive, and
  3. documented pre-cystectomy smoking history by patient interview.

Smoker status, duration of smoking, and number of cigarettes smoked daily were univariately associated with time to recurrence and overall survival. Following multivariate stratification, smoker status, duration of smoking, and number of cigarettes smoked daily were also associated with overall survival. The relative risks of death for current smokers and patients who smoked >40 years were 1.18 and 1.15 times that of nonsmokers.

The authors conclude that current smokers and patients who smoke >40 years before diagnosis have a higher probability of death following radical cystectomy.



Presented by Anirban Mitra, et al. at the American Urological Association (AUA) Annual Meeting - May 14 - 19, 2011 - Walter E. Washington Convention Center, Washington, DC USA

Reported for UroToday by David P. Wood Jr., MD, Professor, Department of Urology, University of Michigan Health System.


The opinions expressed in this article are those of the Contributing Editor and do not necessarily reflect the viewpoints of the American Urological Association.



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