Contemporary Role of Lymph Node Dissection in Genitourinary Cancers: Where Are We in 2023?

Lymphadenectomy during surgery for genitourinary malignancies has varying benefits.

To review contemporary evidence on lymph node dissection in genitourinary cancers.

We performed a collaborative review to summarize current evidence supporting lymph node dissection in urothelial, prostate, kidney, penile, and testis cancers.

We present the evidence on patient selection and recommended dissection templates, and highlight knowledge gaps and ongoing areas of investigation.

Lymph node dissection remains the reference standard for lymph node staging. Pathologic nodal stage informs prognosis and guides adjuvant treatment. Appropriate template and patient selection are paramount to optimize outcomes and capitalize on the selective therapeutic benefits.

Accurate staging with lymphadenectomy is contingent on appropriate template selection. The cumulative benefit will depend on judicious patient selection.

We performed a collaborative review by a diverse group of experts in urology. We reviewed current evidence on lymph node dissection.

European urology oncology. 2023 Nov 16 [Epub ahead of print]

Amanda A Myers, Alberto Briganti, Bradley Leibovich, Seth P Lerner, Marco Moschini, Morgan Rouprêt, Shahrokh F Shariat, Philippe E Spiess, Arnulf Stenzl, Samir S Taneja, Karim A Touijer, Ashish M Kamat

Department of Urology, University of Texas MD Anderson Cancer Center, Houston, TX, USA., Division of Oncology, Unit of Urology, IRCCS Ospedale San Raffaele, Vita-Salute San Raffaele University, Milan, Italy., Department of Urology, Mayo Clinic, Rochester, MN, USA., Dan L. Duncan Cancer Center, Baylor College of Medicine, Houston, TX, USA., Urology, GRC 5 Predictive Onco-Uro, AP-HP, Pitie-Salpetriere Hospital, Sorbonne University, Paris, France., Department of Urology, Comprehensive Cancer Center, Medical University of Vienna, Vienna, Austria., Department of GU Oncology and Tumor Biology, Moffitt Cancer Center, Tampa, FL, USA., Department of Urology, Eberhard Karls University of Tübingen, Tübingen, Germany., Department of Urology, NYU Langone Health, New York, NY, USA., Urology Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY, USA., Department of Urology, University of Texas MD Anderson Cancer Center, Houston, TX, USA. Electronic address: .

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