To measure the changes in treatment patterns for non-muscle invasive bladder cancer before and during the BCG drug shortage.
We used a 5% random sample of Medicare beneficiaries and identified 7971 bladder cancer patients (2648 pre-BCG shortage and 5323 during the shortage) ≥66 years of age who received intravesical treatment within 1 year of diagnosis between 2010-2017. The BCG shortage period was defined from July 2012 ongoing. Full induction treatment with BCG, mitomycin C, gemcitabine, or other intravesical agents was defined as receiving ≥5 of 6 treatments within 60 days. State-level BCG use before and during the drug shortage was compared in US states reporting at least 50 patients in each period. Independent variables included year of index date, age, sex, race, rurality, and region of residence.
BCG utilization rates decreased 5.9% to 33.0% in the shortage period (95% CI (-8.2%)-(-3.7%)). The proportion of patients that completed a full induction course of BCG decreased from 31.0% in the pre-shortage period to 27.6% in the shortage period (p=0.002). 84% of reporting states (16 of 19) had decreased BCG utilization ranging between 5 and 36% compared to pre-shortage rates.
During the BCG drug shortage, eligible bladder cancer patients were less likely to receive gold standard intravesical BCG with a large variation in treatment patterns between US states.
Urology. 2023 Mar 25 [Epub ahead of print]
Brian Chun, Meiqi He, Cameron Jones, Robin Vasan, Nico Gabriel, Bruce L Jacobs, Inmaculada Hernandez, Benjamin J Davies
UPMC, Department of Urology, Pittsburgh, PA. Electronic address: ., UC San Diego, Skaggs School of Pharmacy and Pharmaceutical Sciences, San Diego, CA. Electronic address: ., UPMC, Department of Urology, Pittsburgh, PA. Electronic address: ., UPMC, Department of Urology, Pittsburgh, PA. Electronic address: ., UC San Diego, Skaggs School of Pharmacy and Pharmaceutical Sciences, San Diego, CA. Electronic address: ., UPMC, Department of Urology, Pittsburgh, PA; University of Pittsburgh School of Medicine, Urology Health Services Research Division, Pittsburgh, PA. Electronic address: ., UC San Diego, Skaggs School of Pharmacy and Pharmaceutical Sciences, San Diego, CA. Electronic address: ., UPMC, Department of Urology, Pittsburgh, PA; University of Pittsburgh School of Medicine, Urology Health Services Research Division, Pittsburgh, PA. Electronic address: .