Robot-Assisted, Laparoscopic, and Open Radical Cystectomy: Pre-Operative Data of 1400 Patients From The Italian Radical Cystectomy Registry.

The Italian Radical Cystectomy Registry (RIC) is an observational prospective study aiming to understand clinical variables and patient characteristics associated with short- and long-term outcomes among bladder cancer (BC) patients undergoing radical cystectomy (RC). Moreover, it compares the effectiveness of three RC techniques - open, robotic, and laparoscopic.

From 2017 to 2020, 1400 patients were enrolled at one of the 28 centers across Italy. Patient characteristics, as well as preoperative, postoperative, and follow-up (3, 6, 12, and 24 months) clinical variables and outcomes were collected.

Preoperatively, it was found that patients undergoing robotic procedures were younger (p<.001) and more likely to have undergone preoperative neoadjuvant chemotherapy (p<.001) and BCG instillation (p<.001). Hypertension was the most common comorbidity among all patients (55%), and overall, patients undergoing open and laparoscopic RC had a higher Charlson Comorbidities Index (CCI) compared to robotic RC (p<.001). Finally, laparoscopic patients had a lower G-stage classification (p=.003) and open patients had a higher ASA score (p<.001).

The present study summarizes the characteristic of patients included in the RIC. Future results will provide invaluable information about outcomes among BC patients undergoing RC. This will inform physicians about the best techniques and course of care based on patient clinical factors and characteristics.

Frontiers in oncology. 2022 May 05*** epublish ***

Gian Maria Busetto, Daniele D'Agostino, Michele Colicchia, Katie Palmer, Walter Artibani, Alessandro Antonelli, Lorenzo Bianchi, Aldo Bocciardi, Eugenio Brunocilla, Marco Carini, Giuseppe Carrieri, Luigi Cormio, Ugo Giovanni Falagario, Ettore De Berardinis, Alessandro Sciarra, Costantino Leonardo, Francesco Del Giudice, Martina Maggi, Ottavio de Cobelli, Matteo Ferro, Gennaro Musi, Amelio Ercolino, Fabrizio Di Maida, Andrea Gallina, Carlo Introini, Ettore Mearini, Giovanni Cochetti, Andrea Minervini, Francesco Montorsi, Riccardo Schiavina, Sergio Serni, Claudio Simeone, Paolo Parma, Armando Serao, Mario Salvatore Mangano, Giorgio Pomara, Pasquale Ditonno, Alchiede Simonato, Daniele Romagnoli, Alessandro Crestani, Angelo Porreca

Department of Urology and Renal Transplantation, University of Foggia, Policlinico Riuniti, Foggia, Italy., Department of Urology, Villa Salus Clinic, Mestre, Italy., Department of Urology, Policlinico Abano Terme, Abano Terme, Italy., Department of Internal Medicine and Geriatrics, University Cattolica del Sacro Cuore, Rome, Italy., Department of Urology, Azienda Ospedaliera Universitaria Integrata (A.O.U.I.), Verona, Italy., Department of Urology, University of Bologna, Bologna, Italy., Department of Urology, Niguarda Hospital, Milano, Italy., Department of Urology, University of Florence, Florence, Italy., Department of Maternal-Child and Urological Sciences, Sapienza Rome University, Policlinico Umberto I, Rome, Italy., Department of Urology, European Institute of Oncology (IEO), IRCCS, Milan, Italy., Department of Urology, San Raffaele Hospital and Scientific Institute, Milan, Italy., Department of Urology, Galliera Hospital, Genoa, Italy., Department of Urology, University of Perugia, Perugia, Italy., Department of Urology, University of Brescia, Brescia, Italy., Department of Urology, Azienda Socio Sanitaria Territoriale (ASST) Mantova, Mantova, Italy., Department of Urology, Azienda Ospedaliera di Alessandria, Alessandria, Italy., Department of Urology, Ca' Foncello Hospital, Treviso, Italy., Department of Urology, Azienda Ospedaliero-Universitaria Pisana, Pisa, Italy., Department of Emergency and Organ Transplantation, Urology, Andrology and Kidney Transplantation Unit, University of Bari, Bari, Italy., Department of Surgical, Oncological and Oral Sciences, Section of Urology, University of Palermo, Palermo, Italy., Oncological Urology, Veneto Institute of Oncology (IOV) - Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS), Padua, Italy.

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