Quality-of-Life Outcomes in Female Patients With Ileal Conduit or Orthotopic Neobladder Urinary Diversion: 6-Month Results of a Multicenter Prospective Study.

Radical cystectomy (RC) often affects patients' life as this surgery is a traumatic and invasive event for the patients, with drawbacks on their daily, social, working, and sex life. Such changes in the quality of life (QoL) of patients are commonly studied through retrospective clinical evaluations and rarely with longitudinal studies. To date, studies focusing on functional outcomes, sexual function, and health-related QoL for female patients are lacking. We evaluated 37 patients using EORTC QLQ-C30 (QLQ-30) and Short-Form 36 (SF-36) questionnaires, before and after surgery, at 3 and 6 months of follow-up. The mean values for the emotional functioning in QLQ-C30 as well as the mental health in SF-36 were significantly higher in the ONB group compared to the IC group at 3 months of follow-up. These differences were not significant at 6 months of follow-up. At 6 months of follow-up, the ONB group showed a higher mean score in the physical and role functioning than the IC group. Although there was a statistically significant age difference at baseline of the two groups, none of the results are correlated with age, as demonstrated by Spearman's analysis. The ONB seems to represent the most advantageous solution compared to the IC in terms of QOL at the 6-month follow-up.

Frontiers in oncology. 2022 Apr 12*** epublish ***

Salvatore Siracusano, Agustina Zaka, Pierfrancesco Bassi, Paolo Gontero, Ettore Mearini, Ciro Imbimbo, Alchiede Simonato, Fabrizio Dal Moro, Gianluca Giannarini, Claudio Valotto, Francesco Montorsi, Renzo Colombo, Francesco Porpiglia, Riccardo Bartoletti, Marco Vella, Andrea Minervini, Antonio Benito Porcaro, Federico Romantini, Carlo Vicentini, Renato Talamini, Vincenzo Ficarra, Cristina Lonardi

Department of Life, Health and Environmental Sciences, University of L'Aquila, L'Aquila, Italy., Department of Surgery, Dentistry, Pediatrics and Gynaecology, University of Verona, Verona, Italy., Department of Medicine and Surgery, Rome Catholic University, Rome, Italy., Department of Surgical Science, Turin University, Turin, Italy., Department of Medicine and Surgery, Perugia University, Perugia, Italy., Department of Urology, Federico II Naples University, Naples, Italy., Department of Urology, Palermo University, Palermo, Italy., Department of Urology, Padova University, Padova, Italy., Department of Urology, Udine Hospital, Udine, Italy., Department of Urology, San Raffaele Hospital, Vita e Salute University, Milan, Italy., Department of Urology, Orbassano Hospital, Turin University, Turin, Italy., Department of Urology, Pisa University, Pisa, Italy., Department of Urology, Florence University, Florence, Italy., School of Medicine and Surgery, Verona University, Verona, Italy., Department of Epidemiology, Aviano Oncology Center, Aviano, Italy., Department of Urology, University of Messina, Messina, Italy., Department of Human Sciences, Verona University, Verona, Italy.

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