To investigate the capability of a modified self-administrable comorbidity index recommended in the standard sets for neoplastic diseases published by the International Consortium for Health Outcomes Measurement (ICHOM) to predict 90-day and long-term mortality after radical cystectomy.
A single-center series of 1,337 consecutive patients who underwent radical cystectomy for muscle-invasive or high-risk non-muscle-invasive urothelial or undifferentiated bladder cancer were stratified by the modified self-administrable comorbidity index and Charlson score, respectively. Multivariate logit models (for 90-day mortality) and proportional-hazards models (for overall and non-bladder cancer mortality) were used for statistical workup.
Considering 90-day mortality, both comorbidity indexes contributed independent information when analyzed together with age (p < 0.0001). The Charlson score performed slightly better (area under the curve [AUC] 0.74 vs. 0.72 for the ICHOM-recommended comorbidity index). Considering 5-year overall mortality in 727 patients with complete observation, the performance of both measures was similar (AUC 0.63 vs. 0.62, including age AUC 0.66 for both indexes). With 6-sided stratifications, the modified self-administrable comorbidity index separated the risk groups slightly better (p values for directly neighboring curves: 0.0068-0.1043 vs. 0.0001-0.8100).
The ICHOM-recommended modified self-administrable comorbidity index is capable of predicting 90-day mortality and long-term non-bladder cancer mortality after radical cystectomy similarly to the commonly used Charlson score.
Urologia internationalis. 2020 Jun 15 [Epub ahead of print]
Michael Froehner, Rainer Koch, Ulrike Heberling, Angelika Borkowetz, Matthias Hübler, Vladimir Novotny, Manfred P Wirth, Christian Thomas
Department of Urology, Zeisigwaldkliniken Bethanien Chemnitz, Chemnitz, Germany, ., Department of Urology, University Hospital "Carl Gustav Carus", Technische Universität Dresden, Dresden, Germany., Department of Anesthesiology, University Hospital "Carl Gustav Carus", Technische Universität Dresden, Dresden, Germany.