Identification and Validation of an 18-gene Signature Highly-predictive of Bladder Cancer Metastasis - Beyond the Abstract
To the best of our knowledge, for the first time, we combined the two most widely used external databases and studied the different gene expression status between extreme populations whose outcomes could not be predicted by clinicopathological factors. With external validation with RT-qPCR in a consecutive FUSCC cohort, we first give a clue that NECTIN2 might be a trigger for metastasis in bladder cancer pending larger cohorts and basic research. Most importantly, the 18-gene signature we proposed that is highly predictive of bladder cancer metastasis outperformed three other published signatures in another two GEO datasets.
Written by: Wang Beihe, Clinical Medicine (8-year M.D.program) Shanghai Medical College of Fudan University
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