A Comparison of Periurethral Cleaning between Normal Saline and Savlon Solutions before Indwelling Urinary Catheterization in Reducing Catheter-Associated Bacteriuria: A Randomized Controlled Study.

Catheter-associated urinary tract infection (CAUTI) is a common nosocomial infection. However, there have been no randomized controlled studies comparing efficacy of antiseptic solutions for reducing CAUTI. This study aimed to compare the efficacy of normal saline solution (NSS) and Savlon solution.

A randomized controlled, non-inferiority, cross-over study was conducted to compare the two solutions in terms of the incidence of significant bacteriuria (SB) on day 5 after Foley catheterization. Patients admitted in a tertiary referral hospital from June 2018 to August 2019, were participated. The acceptable prespecified non-inferiority margin was set to be 10%.

There were 265 and 275 patients in NSS and Savlon groups, respectively. The incidence of CAUTI was 2.65/1,000 catheter-days and the median duration of catheterization was 5 (IQR 4, 7) days. The incidences of SB in NSS and Savlon groups had no significant difference, as indicated by the adjusted difference of 0.6 (95% CI of the difference: -3.1 to 4.2).

This study was the first randomized controlled study in patients from various units to compare the efficacy of the two solutions in the periurethral cleaning process. The study demonstrated non-inferiority of NSS to Savlon solution.

TCTR20180518001.

International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases. 2021 Feb 23 [Epub ahead of print]

Sarin Khahakaew, Gompol Suwanpimolkul, Thanittha Wongkeskij, Napawan Punakabutra, Chusana Suankratay

Division of Infectious Diseases, Department of Medicine, Faculty of Medicine, Chulalongkorn University, Bangkok 10330, Thailand. Electronic address: ., Division of Infectious Diseases, Department of Medicine, Faculty of Medicine, Chulalongkorn University, Bangkok 10330, Thailand., Department of Microbiology, King Chulalongkorn Memorial Hospital, Bangkok 10330, Thailand.

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