Favorable Outcomes of Repeat Electrofulguration Procedures in Women with Antibiotic-Refractory Recurrent Urinary Tract Infections.

To evaluate the efficacy of repeat endoscopic electrofulguration in women with antibiotic-refractory, recurrent urinary tract infections (RUTIs) with persistent symptoms after one electrofulguration.

An institutional review board-approved, prospectively maintained database of non-neurogenic women with RUTIs, persistent symptoms and endoscopic findings of bladder wall inflammation after one electrofulguration, and minimum 6 months follow-up was reviewed. Endoscopic success was defined as complete resolution of previous lesions without new lesions seen during office cystoscopy 6 months after second electrofulguration. Clinical success was defined as no urinary tract infections at last follow-up; improvement as 1-2 treated infections/year; and failure as ≥ 3 treated infections/year, daily antibiotic suppression, or another electrofulguration (third or fourth).

From 2006-2018, 58/70 (83%) women with median age 70 years and median follow-up 26 months were included, and 53/58 had endoscopic data 6 months post-second electrofulguration. Endoscopic success was noted in 26 (49%), and 21/26 had < 3 UTIs within the last year of follow-up, versus 2/27 (7%) with endoscopic failure (p = 0.001). Among those with clinical failure, 6/30 (20%) remained on suppressive antibiotics, 9/30 (30%) required intravenous antibiotic courses, and two proceeded to cystectomy. Of 24 women who underwent a third electrofulguration, 11/24 (46%) were clinically successful or improved at median 22 months follow-up. Urine cultures from the year of last follow-up revealed extended-spectrum beta lactamase producing strains (50%) and strains resistant to > 3 antibiotics (43%).

Women with persistent RUTIs following one electrofulguration may benefit from a second or even third procedure.

Urology. 2020 Aug 29 [Epub ahead of print]

Jacqueline A Chavez, Alana L Christie, Philippe E Zimmern

Department of Urology, UT Southwestern Medical Center, 5323 Harry Hines Blvd, Dallas, TX 75390-9110., Simmons Comprehensive Cancer Center, UT Southwestern Medical Center, 6000 Harry Hines Blvd, Dallas, TX 75390-8852., Department of Urology, UT Southwestern Medical Center, 5323 Harry Hines Blvd, Dallas, TX 75390-9110. Electronic address: .

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