To review current evidence on gene expression in women with urinary incontinence and pelvic organ prolapse (POP).
Our literature review revealed numerous genes that are associated with urinary incontinence and POP. For overactive bladder and urge urinary incontinence, four genes were highlighted: adrenergic receptor β3, Rho guanine nucleotide exchange factor 10, Rho-associated coiled-coil containing protein kinase 2, and potassium two pore domain channel subfamily K member-1. For Stress Urinary incontinence (SUI), 13 genes were included: skin-derived antileukoproteinase, collagen type XVII alpha 1 chain, plakophilin 1, keratin 16, decorin, biglycan, protein bicaudal D homolog 2, growth factor receptor-bound protein 2, signal transducer and activator of transcription 3, apolipoprotein E, Golgi SNAP receptor complex member 1, fibromodulin, and glucocerebrosidase. For POP seven genes were identified: homeobox A13, matrix metallopeptidase 9, estrogen receptor 2, collagen type XIV alpha 1 chain, collagen type V alpha 1 chain, collagen type IV alpha 2 chain, and catenin beta 1.
The current review highlights many genes which are potential biomarkers and targets for drug development.
Current opinion in obstetrics & gynecology. 2020 Sep 29 [Epub ahead of print]
Ilaha Isali, Jasmin Abdeldayem, Sherif El-Nashar
Department of Urology., Department of Obstetrics and Gynecology, University Hospitals Cleveland Medical Center.