Impact of intravesical onabotulinumtoxinA on sexual function in women with OAB

Urgency urinary incontinence (UUI), and the symptoms of overactive bladder (OAB) have a negative impact on female sexual function. The aim of this study was to investigate the effect of intravesical onabotulinumtoxinA (Botox) injection on sexual function in women with OAB, using the multi domain Female Sexual Function Index (FSFI) questionnaire.

Sixty-eight sexually active women with idiopathic OAB with at least one episode of UUI and ≥8 micturitions per 24 h were recruited. Patients completed the FSFI questionnaire before and 12 weeks after treatment with intravesical onabotulinumtoxinA injections. Baseline scores were compared with a control group of age-matched healthy women.

Fifty-six women completed the study. At baseline OAB patients reported decreased quality of sexual function in all domains measured with FSFI, in comparison to healthy women (median 21.8 vs. 26.3, P < 0.001). Over 90% of participants reported clinically relevant improvements in sexual function, with statistically significant changes in mean scores in all six domains.

Intravesical Botox injections provide improvement in sexual function in women with OAB. Neurourol. Urodynam. 9999:XX-XX, 2016. © 2016 Wiley Periodicals, Inc.

Neurourology and urodynamics. 2016 [Epub ahead of print]

Pawel Miotla, Rufus Cartwright, Katarzyna Skorupska, Michal Bogusiewicz, Ewa Markut-Miotla, Konrad Futyma, Tomasz Rechberger

2nd Chair and Department of Gynaecology, Medical University of Lublin, Lublin, Poland. ., Department of Epidemiology and Biostatistics, Imperial College London, London, UK., 2nd Chair and Department of Gynaecology, Medical University of Lublin, Lublin, Poland., Department of Paediatric Pulmonology and Rheumatology, Medical Univeristy of Lublin, Lublin, Poland.

Go Beyond the Abstract with a commentary written by the author