Effects of solifenacin in patients with neurogenic detrusor overactivity as a result of spinal cord lesion - Abstract

Study design: Retrospective analysis.

Objectives: To investigate the urodynamic effects of solifenacin treatment for neurogenic detrusor overactivity (NDO) in patients with spinal cord injury (SCI).

Setting: Paraplegic center in Switzerland.

Methods: Retrospective analysis of case histories and urodynamic data of 35 SCI patients receiving solifenacin for treatment of NDO between 2008 and 2012. Patients were categorized as being at risk of renal damage when maximum detrusor pressure was >40 cm H2O or detrusor compliance was < 20 ml cm-1 H2O.

Results: Solifenacin treatment was initiated 7.3 years after SCI. Most patients (63%) had already been taking other antimuscarinic drugs. After 13.1 months (median, interquartile range 6.1-19.5 months), solifenacin treatment had resulted in significant (P< 0.03) improvements in bladder capacity (median +30.0 ml), maximum detrusor pressure (median -7.0 cm H2O), reflex volume (median +62.5 ml) and detrusor compliance (median +25.0 ml cm-1 H2O). Furthermore, fewer patients presented with a risk of renal damage. However, this difference was not significant (P>0.1). The number of patients suffering from incontinence had not changed significantly. Eight and two patients discontinued solifenacin treatment as a result of insufficient efficacy and intolerable adverse events, respectively. One patient had discontinued solifenacin treatment without further explanation.

Conclusion: Solifenacin treatment significantly improved bladder capacity, detrusor compliance, reflex volume and maximum detrusor pressure. Solifenacin treatment seems to be an effective oral treatment of NDO after SCI.

Written by:
Krebs J, Pannek J.   Are you the author?
Clinical Trial Unit, Swiss Paraplegic Centre, Nottwil, Switzerland.

Reference: Spinal Cord. 2012 Dec 18. Epub ahead of print.
doi: 10.1038/sc.2012.164

PubMed Abstract
PMID: 23247012

UroToday.com Overactive Bladder (OAB) Section