Overactive bladder induces transient hypertension

Several studies have shown the relationship between lower urinary tract symptoms and autonomic imbalance. We investigated the relationship between detrusor overactivity (DO) or urgency, and transient increase in blood pressure as a type of hypertension related to sympathetic hyperactivity. Study 1: we enrolled 14 male patients with DO and 10 without DO. We measured the overactive bladder symptom score (OABSS) and blood pressure during cystometry. Study 2: we enrolled 14 men patients with overactive bladder (OAB) and 8 without OAB. We measured OABSS and blood pressure using a 24-h ambulatory device.

Study 1: the mean systolic pressure was significantly higher at urgency or SDV than at the other measurement points in the DO group (161.3 ± 23.2 vs. 134.5 ± 16.3, 137.8 ± 15.3, or 139.5 ± 14.8 mmHg). Study 2: the mean systolic pressure was significantly higher at the measurement points before micturition than at the points unrelated to micturition in the OAB group (159.7 ± 24.9 vs. 124.9 ± 13.8 mmHg). In conclusion, DO or urgency induces a transient increase of blood pressure, suggesting that OAB induces a type of hypertension before micturition.

BMC research notes. 2018 Mar 27*** epublish ***

Kazumasa Torimoto, Yoshihiro Matsumoto, Daisuke Gotoh, Yosuke Morizawa, Makito Miyake, Shoji Samma, Nobumichi Tanaka, Akihide Hirayama, Kiyohide Fujimoto

Department of Urology, Nara Medical University, 840 Shijo-cho, Kashihara, Nara, 634-8522, Japan. ., Department of Urology, Hoshigaoka Medical Center, 4-8-1 Hoshigaoka, Hirakata, Osaka, 573-8511, Japan., Department of Urology, Nara Medical University, 840 Shijo-cho, Kashihara, Nara, 634-8522, Japan., Department of Urology, Nara Prefecture General Medical Center, 1-30-1 Hiramatsu, Nara, Nara, 631-0846, Japan., Department of Urology, Kindai University Nara Hospital, 1248-1 Otoda-cho, Ikoma, Nara, 630-0227, Japan.

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