Pain in interstitial cystitis/bladder pain syndrome: Do characteristics differ in ulcerative and non-ulcerative subtypes? - Abstract

INTRODUCTION AND HYPOTHESIS: Key differences between interstitial cystitis/bladder pain syndrome (IC/BPS) subtypes (with and without Hunner's ulcer) have been noted.

We hypothesized that pain characteristics in women grouped by IC/BPS subtype would differ.

METHODS: A survey was mailed to 749 women to assess IC/BPS pain and other characteristics. Cystoscopy/hydrodistention reports were reviewed for presence/absence of Hunner's ulcer. The McGill Pain Questionnaire Short Form© (MPQ-SF), Brief Pain Inventory (BPI), and Interstitial Cystitis Symptom and Problem Indices (ICSI-PI) assessed symptoms. Data were analyzed with Pearson's chi-square, Fisher's exact, t tests, and Wilcoxon rank tests.

RESULTS: Of the 214 women that returned a survey (36 ulcerative and 178 non-ulcerative IC/BPS), similar proportions in each group reported that certain foods, exercise, and/or stress triggered symptoms. Fewer ulcerative patients reported pain with vaginal penetration than non-ulcerative (5/33, 15.2 % vs 76/160, 47.5 %; p = 0.0006). On the BPI, the ulcerative and non-ulcerative groups reported similar numbers of painful areas (mean 4.1 ± 6.1 and 4.1 ± 3.8; p = 0.33), and lower abdominal/pelvic pain was reported most (13/35, 37 % vs 79/172, 46 %; p = 0.34) followed by lower back pain (12/35, 34 % vs 69/172, 40 %; p = 0.52). Even though ICSI-PI, MPQ-SF, and BPI scores/responses did not differ, on the MPQ-SF the three words most frequently used by ulcerative patients to describe their pain were sharp, stabbing, and hot burning, and in non-ulcerative were aching, cramping, and tender.

CONCLUSIONS: These measures did not reveal any significant differences in pain between subtypes. More research is needed in larger samples to determine whether differences exist.

Written by:
Killinger KA, Boura JA, Peters KM.   Are you the author?
William Beaumont Hospital, 3535 W. 13 Mile Road Ste. 438, Royal Oak, MI, 48073, USA.

Reference: Int Urogynecol J. 2012 Dec 4. Epub ahead of print.
doi: 10.1007/s00192-012-2003-9

PubMed Abstract
PMID: 23208005 Interstitial Cystitis/Painful Bladder Section