To examine the prevalence of comorbid conditions in a nationwide population of men and women with IC/BPS utilizing a more heterogeneous sample than most studies to date.
Using the Veterans Affairs Informatics and Computing Infrastructure, we identified random samples of male and female patients with and without an ICD-9/ICD-10 diagnosis of IC/BPS. Presence of comorbidities (NUAS [chronic fatigue syndrome, fibromyalgia, irritable bowel syndrome, migraines], back pain, diabetes, and smoking) and psychosocial factors (alcohol abuse, post-traumatic stress disorder, sexual trauma, and history of depression) were determined using ICD-9 and ICD-10 codes. Associations between these variables and IC/BPS status were evaluated while adjusting for the potential confounding impact of race/ethnicity, age, and gender.
Data was analyzed from 872 IC/BPS patients (355 [41%] men, 517 [59%] women) and 558 non-IC/BPS patients (291 [52%] men, 267 [48%] women). IC/BPS patients were more likely than non-IC/BPS patients to have a greater number of comorbidities (2.72+/-1.77 vs 1.73+/-1.30, p<0.001), experience one or more NUAS (chronic fatigue syndrome, fibromyalgia, irritable bowel syndrome, and migraines) (45% [388/872] vs. 18% [101/558]; p<0.001) and had a higher prevalence of at least one psychosocial factor (61% [529/872] v. 46% [256/558]; p<0.001). Differences in the frequencies of comorbidities between patients with and without IC/BPS were more pronounced in female patients.
These findings validate the findings of previous comorbidity studies of IC/BPS in a more diverse population.
Urology. 2021 Apr 23 [Epub ahead of print]
Bethany F Laden, Catherine Bresee, Amanda De Hoedt, Kai B Dallas, April Scharfenberg, Roopali Saxena, Justin F Senechal, Kamil E Barbour, Jayoung Kim, Stephen J Freedland, Jennifer T Anger
Urology Section, Department of Surgery, Veterans Affairs Health Care System, Durham, NC. Electronic address: ., Department of Biostatistics and Bioinformatics Research Center, Cedars-Sinai Medical Center, Los Angeles, CA. Electronic address: ., Urology Section, Department of Surgery, Veterans Affairs Health Care System, Durham, NC. Electronic address: ., Department of Surgery, Division of Urology, Cedars-Sinai Medical Center, Los Angeles, CA. Electronic address: ., Urology Section, Department of Surgery, Veterans Affairs Health Care System, Durham, NC. Electronic address: ., Urology Section, Department of Surgery, Veterans Affairs Health Care System, Durham, NC. Electronic address: ., Urology Section, Department of Surgery, Veterans Affairs Health Care System, Durham, NC. Electronic address: ., National Center for Chronic Disease Prevention and Health Promotion, CDC, Atlanta, GA. Electronic address: ., Department of Surgery, Division of Urology, Cedars-Sinai Medical Center, Los Angeles, CA. Electronic address: ., Urology Section, Department of Surgery, Veterans Affairs Health Care System, Durham, NC; Department of Surgery, Division of Urology, Cedars-Sinai Medical Center, Los Angeles, CA. Electronic address: ., Department of Surgery, Division of Urology, Cedars-Sinai Medical Center, Los Angeles, CA. Electronic address: .